AFFINILUTE™ MIP - NSAIDs

Selective SPE sorbent for extraction of NSAIDs from complex samples e.g. waste water samples

The widespread use of NSAIDs can lead to these compounds reaching wastewater treatment plants and hence groundwater. AFFINILUTE MIP NSAIDs, provides for NSAID quantification in waste and ground water.

Non-steroidal anti-inflammatory drugs are pharmacologically active compounds used to treat pain, inflammation and fever. Their widespread use can lead to NSAIDs reaching wastewater treatment plants and since they cannot be completely removed, the compounds can reach the groundwater and even domestic water. Ibuprofen, diclofenac and naproxen are non-steroidal anti-inflammatory drugs, which have analgesic and antipyretic activities. Clofibric acid is an active metabolite of clofibrate, etofibrate and etofyllinclofibrate. These compounds are used as blood lipid regulators. Because of the pharmacological activity of the NSAIDs, the concentration needs to be accurately quantified in environmental samples such as waste, ground and drinking waters.

Features and Applications
The acidic, polar NSAIDSs are normally analyzed by LC-MS/MS. However, when working with complex matrices, a drawback is the sensitivity of this technique to matrix effects (ion suppression). Furthermore, NSAIDs are often present at very low concentrations in water samples. In order to minimize these problems pre-concentration and sample clean-up steps are required before the compounds can be analyzed chromatographically. Conventional SPE methods NSAID extraction from water samples have shown low recoveries and a lack of selectivity.

Both recoveries and selectivity are considerably improved by incorporating AFFINILUTE MIP - NSAID in the pre-concentration step. AFFINILUTE MIP - NSAIDs has been optimized for the extraction of diclofenac, ibuprofen, clofibric acid and naproxen with high recoveries and reproducibility. Other NSAIDs with related chemical structures would also be expected to be extracted.